Recently, buildings are designed considering mainly their energy performance with a massive use of mechanical and building automation systems to control them, often losing the relationship to local climate and the possibility to exploit free and passive solutions. NV can be a good alternative that meets human comfort conditions and increase users’ health, as well as allowing to save energy and greenhouse gas emissions to the atmosphere (both locally and globally). NV relies on natural forces. For this reason, it is considered as one of the main techniques to lower buildings’ energy consumption. Moreover, NV was observed to significantly enlarge the acceptable range of indoor thermal comfort, with respect to mechanical ventilation (MV) systems and this allowed the possibility to accept an increase of indoor temperature when outdoor temperature is higher. Moreover, it was observed that NV also led to benefits related with symptoms associated with Sick Building Syndrome, satisfaction with the environment, productivity, and job satisfaction. For these reasons, NV techniques are worth analysing in the framework of climate responsive and net positive energy buildings.