First, the building’s technical and operational status will be described, and the tasks for the refurbishment will be defined. Based on the possibilities of the current building, the potential of the energy savings, application of renewable resources and measures on the HVAC system are calculated and analysed. The potential of the operation scheme is then identified. A preliminary design is necessary for improvement of the analyses, feasibility evaluation, and cost calculation. Specific ARV innovations are tested and evaluated in this step. The most detailed design is carried out and realized with a demo building, such a healthcare centre like in the case of Karvina. The building of the healthcare centre will reach the at least nZEB level if no extra measures are applied. Digital twins are crucial tool that will provide support for the design process. The input from the model is used to shape the design from the preliminary stage to the completed building and beyond. Knowledge, experience, and data will be a catalysator of change on a larger scale. Stakeholders can get comprehensive information on how the innovations and technical measures can affect the buildings’ behaviour.