First, the building’s technical and operational status is assessed and refurbishment tasks are defined. Based on the existing building conditions, the potential for energy savings, the use of renewable energy sources, and HVAC system improvements are calculated and analysed, together with the potential of different operational schemes. A preliminary design is then developed to refine the analysis, assess feasibility, and estimate costs, during which specific ARV innovations are tested and evaluated. The detailed design is subsequently developed and implemented in a demonstration building, such as a healthcare centre, as in the case of Karviná. The healthcare centre is designed to reach at least the nZEB level without additional measures. Digital twins play a crucial role by supporting the design process from the preliminary stage through to the completed building and beyond. The data, knowledge, and experience generated act as a catalyst for wider change, enabling stakeholders to understand how innovations and technical measures influence building performance.